Graphic Software Glitches

I've had issues with Photoshop randomly deciding that at certain points during my time using it (obviously when I'm hard at work) I seem to get some odd issue where the tools just don't seem to respond to me selecting them via my mouse. Randomly annoying and made worse by the fact that they seem to work with the key shortcuts instead. A quick restart of Photoshop seems to do the trick until the next time but it's insanely annoying how random of an error it is lol.